中文网站正在持续更新中,请密切关注我们康肽生物的最新动态,或点击访问右上角的英文官方网站 www.phoenixpeptide.com
PHOENIX PHARMACEUTICALS, INC. TOP HOME PAGE
Top » Catalog English Version | My Account | 联系我们 | China



 多肽



 标记多肽 



 多肽激素文库



 抗体 



 免疫试剂盒 



 生物标志物阵列 



 多肽样品检测



 自定义肽链合成及GMP



 产品目录索取



 样品准备



 提问和解答


Diabetes

多肽/蛋白质生物标志物和糖尿病治疗

中枢神经系统中的多肽/蛋白质对葡萄糖动态平衡的影响

Related Products

Adropin

Amylin

Exendin

FGF-19

FGF-21

FGF-23

Ghrelin

GLP-1

GLP-2

Glucagon

GRP

INSL-5

Insulin Intermedin Irisin

Leptin

Neuronostatin NPY

Oxyntomodulin

Urocortin

Visfatin/Nampt

VIP

Xenin

 

Click to Collapse

Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.

Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide expressed in the nervous system and in endocrine cells, e.g. in pancreatic islets. CART deficient mice exhibit islet dysfunction, impaired insulin secretion and increased body weight. A mutation in the CART gene in humans is associated with reduced metabolic rate, obesity and diabetes. Furthermore, CART is upregulated in islets of type-2 diabetic rats and regulates islet hormone secretion in vitro. While the function of CART in the nervous system has been extensively studied, there is no information on its expression or function in white adipose tissue. CART mRNA and protein were found to be expressed in both subcutaneous and visceral white adipose tissue from rat and man. Stimulating rat primary adipocytes with CART significantly potentiated isoprenaline-induced lipolysis, and hormone sensitive lipase activation (phosphorylation of Ser 563). On the other hand, CART significantly potentiated the inhibitory effect of insulin on isoprenaline-induced lipolysis. CART inhibited insulin-induced glucose uptake and lipogenesis, which was associated with inhibition of PKB phosphorylation. In conclusion, CART is a novel constituent of human and rat adipocytes and affects several biological processes central in both lipid- and glucose homeostasis. Depending on the surrounding conditions, the effects of CART are insulin-like or insulin-antagonistic.

Banke E et al, RegulPept. 2013 Mar 10;182:35-40. doi: 10.1016/j.regpep.2012.12.011. Epub 2013 Jan 11.

Click to Expand

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.

Bordicchia M, et al., J Clin Invest. 2012 Mar 1;122(3):1022-36. doi: 10.1172/JCI59701. Epub 2012 Feb 6.

Click to Expand

Interleukin-1β Downregulates RBP4 Secretion in Human Adipocytes.

Kotnik P et al, PLoS One. 2013;8(2):e57796. doi: 10.1371/journal.pone.0057796. Epub 2013 Feb 27.

Click to Expand

Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue.

Wellhöner P et al., Int J Obes (Lond). 2012 May;36(5):703-8. doi: 10.1038/ijo.2011.105. Epub 2011 May 31.

Click to Expand

Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling.

Bandyopadhyay GK et al, J Biol Chem. 2012 Jun 29;287(27):23141-51. doi: 10.1074/jbc.M111.335877. Epub 2012 Apr 25.

Click to Expand

Maternal and fetal adropin levels in gestational diabetes mellitus.

Celik E et al, Perinat Med. 2013 Jan 9:1-6. doi: 10.1515/jpm-2012-0227. [Epub ahead of print]

Click to Expand

Biophysical characterization of a binding site for TLQP-21, a naturally occurring peptide which induces resistance to obesity.

Cassina V, Torsello A, Tempestini A, et al, Biochim Biophys Acta. 2013 Feb;1828(2):455-60. doi: 10.1016/j.bbamem.2012.10.023. Epub 2012 Oct 30.

Click to Expand

Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.

Ramos-Álvarez I, Mol Cell Endocrinol. 2013 Mar 10;367(1-2):109-15. doi: 10.1016/j.mce.2012.12.025. Epub 2013 Jan 3.


分类搜索
关键字搜索
按字母搜索
A B C D E F G H I J K L M N
O P Q R S T U V W X Y Z

Copyright © 2024 PHOENIX BIOTECH