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Diabetes

多肽/蛋白质生物标志物和糖尿病治疗

中枢神经系统中的多肽/蛋白质对葡萄糖动态平衡的影响

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Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.

Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide expressed in the nervous system and in endocrine cells, e.g. in pancreatic islets. CART deficient mice exhibit islet dysfunction, impaired insulin secretion and increased body weight. A mutation in the CART gene in humans is associated with reduced metabolic rate, obesity and diabetes. Furthermore, CART is upregulated in islets of type-2 diabetic rats and regulates islet hormone secretion in vitro. While the function of CART in the nervous system has been extensively studied, there is no information on its expression or function in white adipose tissue. CART mRNA and protein were found to be expressed in both subcutaneous and visceral white adipose tissue from rat and man. Stimulating rat primary adipocytes with CART significantly potentiated isoprenaline-induced lipolysis, and hormone sensitive lipase activation (phosphorylation of Ser 563). On the other hand, CART significantly potentiated the inhibitory effect of insulin on isoprenaline-induced lipolysis. CART inhibited insulin-induced glucose uptake and lipogenesis, which was associated with inhibition of PKB phosphorylation. In conclusion, CART is a novel constituent of human and rat adipocytes and affects several biological processes central in both lipid- and glucose homeostasis. Depending on the surrounding conditions, the effects of CART are insulin-like or insulin-antagonistic.

Banke E et al, RegulPept. 2013 Mar 10;182:35-40. doi: 10.1016/j.regpep.2012.12.011. Epub 2013 Jan 11.

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Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.

Bordicchia M, et al., J Clin Invest. 2012 Mar 1;122(3):1022-36. doi: 10.1172/JCI59701. Epub 2012 Feb 6.

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Interleukin-1β Downregulates RBP4 Secretion in Human Adipocytes.

Kotnik P et al, PLoS One. 2013;8(2):e57796. doi: 10.1371/journal.pone.0057796. Epub 2013 Feb 27.

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Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue.

Wellhöner P et al., Int J Obes (Lond). 2012 May;36(5):703-8. doi: 10.1038/ijo.2011.105. Epub 2011 May 31.

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Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling.

Bandyopadhyay GK et al, J Biol Chem. 2012 Jun 29;287(27):23141-51. doi: 10.1074/jbc.M111.335877. Epub 2012 Apr 25.

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Maternal and fetal adropin levels in gestational diabetes mellitus.

Celik E et al, Perinat Med. 2013 Jan 9:1-6. doi: 10.1515/jpm-2012-0227. [Epub ahead of print]

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Biophysical characterization of a binding site for TLQP-21, a naturally occurring peptide which induces resistance to obesity.

Cassina V, Torsello A, Tempestini A, et al, Biochim Biophys Acta. 2013 Feb;1828(2):455-60. doi: 10.1016/j.bbamem.2012.10.023. Epub 2012 Oct 30.

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Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.

Ramos-Álvarez I, Mol Cell Endocrinol. 2013 Mar 10;367(1-2):109-15. doi: 10.1016/j.mce.2012.12.025. Epub 2013 Jan 3.


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