Evidence of CNS

Catalog #	043-24
Standard Size	200 µg
Sequence	Ac - Nle - Asp - His - D - Nal(2) - Arg - Trp - Lys - NH2 Amide Bridge: Asp3 - Lys8
M.W	1075.3
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution.
Storage Condition	Store peptide in DRY form at 0-5°C.
Appearance	White powder
Content	The contents of this vial have been accurately determined to contain 200µg of NET peptide.
HPLC Analysis	Purity ≥ 95%
Additional articles	For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions. Please click the reference tab on the top to get more articles that use this peptide.

Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this peptide:

Gregory M. Sutton et al., A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally
Peptides. 2008 January; 29(1): 104-111., doi: 10.1016/j.peptides.2007.10.014

Smith et al. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances
J Physiol. 2007 Jan 15;578(Pt 2):425-38.

Lin et al. Enterostatin inhibition of dietary fat intake is modulated through the melanocortin system
Peptides. 2007 Mar;28(3):643-9.

Vulliémoz et al. Melanocortin modulation of inflammatory cytokine and neuroendocrine responses to endotoxin in the monkey.
Endocrinology. 2006 Apr;147(4):1878-83.

Gotoh et al. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.
Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R202-7.

Starowicz et al. Inhibition of morphine tolerance by spinal melanocortin receptor blockade.
Pain. 2005 Oct;117(3):401-11.

Yang et al. Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of dopamine in tuberoinfundibular neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin.
Neuropharmacology. 2004 Dec;47(7):1070-80. 

Starowicz et al. Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats.
Neurosci Lett. 2004 Mar 25;358(2):79-82.

Williams et al. Food deprivation after treatment blocks the multiple-day hyperphagic response to SHU9119 administration.
Brain Res. 2004 Jan 23;996(2):180-6.

Benoit et al. The catabolic action of insulin in the brain is mediated by melanocortins.
J Neurosci. 2002 Oct 15;22(20):9048-52.

Aizawa-Abe et al. Pathophysiological role of leptin in obesity-related hypertension
J Clin Invest. 2000 May;105(9):1243-52.

Other Information:

Antagonist of rat MC3 and mouse MC4 receptors - Wei Fan et al., Nature 385, 165-168 (1997)

For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.
Please click the reference tab on the top to get more articles that use this peptide.