Description:

Selective inhibitor of TGF-beta type-I receptor (IC50 59 nM for TGF-beta RI vs. 400 nM for TGF-beta RII).

[3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole

Ref: Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-μ type I receptor kinase domain. J. Med. Chem. 46 3953, 2003.

Biological Activity: In a cell-based assay measuring the activation of a SMAD reporter gene, this compound gives IC50 around 100-200 nM.

CAS: 396129-53-6