Beta-Neoendorphin-Dynorphin Precursor Schematic (Human)

Catalog #	021-03
Standard Size	500 µg
Sequence	Tyr - Gly - Gly - Phe - Leu - Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - Trp - Asp - Asn - Gln
Species	Human, Rat, Mouse, Porcine
M.W	2147.51
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution.
Storage Condition	Store peptide in DRY form at 0-5°C.
Content	The contents of this vial have been accurately determined to contain 500µg of NET peptide.
HPLC Analysis	Purity ≥96%
Additional articles	For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.

Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this peptide:

Chen et al. Dynorphin peptides differentially regulate the human kappa opioid receptor
Life Sci. 2007 Mar 20;80(15):1439-48.

Chen et al. Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists.
J Pharmacol Exp Ther. 2006 Nov;319(2):765-75.

Wang et al. Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation.
J Pharmacol Exp Ther. 2003 Dec;307(3):1127-34.

Li et al. Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate.
J Biol Chem. 2002 Jul 26;277(30):27545-52.

Liu et al. Femtomolar Concentrations of Dynorphins Protect Rat Mesencephalic Dopaminergic Neurons against Inflammatory Damage
J Pharmacol Exp Ther. 2001 Sep;298(3):1133-41.

Yakovleva et al. p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.
J Biol Chem. 2001 May 11;276(19):15650-8.

For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.