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Small Molecule Compounds

Phoenix offers 20 anti-cancer small molecules with competitive prices and purities

Catalog Number
Product Name
Synonym
Function
Standard Size
Price
ARQ-197 Tivantinib Tivantinib is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity.
5 mg
$245
Axitinib AG-013736 Axitinib inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
25 mg
$40
BEZ235 NVP-BEZ235 BEZ235 inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
10 mg
$40
Bosutinib SKI-606 SKI-606 inhibited migration of breast cancer cell lines
25 mg
$38
Canertinib

CI-1033
PD-183805

Canertinib is a pan-erbB tyrosine kinase inhibitor.
5 mg
$160
CP-690550 Tasocitinib The somatic activating janus kinase 2 mutation (JAK2)V617F is detectable in most patients with polycythemia vera (PV).
10 mg
$72
Imatinib Gleevec CGP57148B STI571 A reversible tyrosine kinase inhibitor effective in treatment of chronic myelogenous leukemia(CML), gastrointestinal stromal tumors, eosinophilic disorders, and systemic mast cell disease.
100 mg
$30
Lapatinib Tykerb GW572016 Lapatinib was found to have IC50 values against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively, and IC50 > 10000nM against c-Raf-1, MEK, ERK, CDK1, CDK2, p38 and VEGFR-2.
25 mg
$20
Motesanib AMG-706 Motesanib administered small molecule antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem cell factor receptors.
10 mg
$178
MP-470 Amuvatinib MP470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRa, Flt3
10 mg
$510
Nilotinib AMN107 Tasigna AMN107 inhibited the proliferation of Ba/F3 cells expressing p210- and p190-Bcr-Abl, or K562 and Ku-812F cells with IC50 values < 12 nM.
25 mg
$35
OSI-906   OSI-906 is a selective and orally active inhibitor of the insulin-like growth factor-1 receptor (IGF-1R).
5 mg
$175
Pazopanib GW-786034 Votrient Pazopanib showed good potency against all the human VEGFR receptors with an IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.
25 mg
$75
Saracatinib AZD0530 AZD0530 is highly selective for Src and Abl kinases against a large range of kinases (VEGFR2, FGFR, c-Kit, Aur-3 etc. > 5 µM).
10 mg
$65
Sorafenib

Nexavar
BAY 43-9006

Sorafenib is an inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
500 mg
$80
Sunitinib Sutent
SU-11248
SU11248 inhibited FLT3-ITD phosphorylation, VEGF- and FGF-induced proliferation of HUVECs and PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRα or PDGFRβ
100 mg
$30
Tandutinib MLN518 CT53518 tandutinib inhibited FLT3 ,PDGFR, and KIT, IL-3-independent growth and FLT3-ITD auto-phosphorylation, and proliferation of human leukemia cell lines containing FLT3-ITD mutations
25 mg
$58
Tozasertib VX-680
MK-0457
VX-680 is an inhibitor of Aurora-A,-B and -C kinases with apparent inhibition constant values of 0.6, 18, 4.6 nM respectively.
10 mg
$48
Vandetanib Zactima ZD6474 Vandetanib is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor. It significantly prolonged the time to metastasis in an intravenous model of TKKK metastasis.
25 mg
$64
Vatalanib

PTK-787
ZK-222584 CGP79787D

PTK787/ZK 222584 inhibits the VEGF-induced phosphorylation
25 mg
$48

Diabetes and metabolic diseases

Catalog Number

Product Name

Function

Standard Size

Price

001-16

AdipRon

Producing effects similar to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice.  It can also shifts the physiological profile of mice fed excess calories towards that of mice on a standard diet, but also modulates longevity pathways to prolong lifespan in mice.

1 mg

$80

001-17

IDE inhibitor 6bK

To regulates the abundance and signalling of glucagon and amylin, in addition to that of insulin. Under physiological conditions that augment insulin and amylin levels, such as oral glucose administration, acute IDE inhibition leads to substantially improved glucose tolerance and slower gastric emptying.

0.5 mg

$250

001-18

GLP-1 enhancer N55

Enhance GLP-1-dependent cAMP production and GLP-1R endocytosis in a dose-dependent and saturable manner.

100 µg

$300

032-51

OEA (Oleoylethanolamide)

OEA is an endogenous bioactive lipid-derived factor able to inhibited food intake and regulate glucose by activation of PPAR-alpha & GPR119

1 mg

$50

080-58A

XAV-939

XAV-939 specifically inhibits tankyrase PARP activity and selectively inhibits Wnt/β-catenin-mediated transcription.

2 mg

$59

080-57A

IWP-2

A small molecular produce mediated disruption of Wnt dependent signaling pathway 

2 mg

$62

080-56A

CHIR99021

 glycogen synthase kinase 3 (GSK3) inhibitor with IC50 less than 10 nM. Compared to other GSK-3 inhibitors, CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases CDKs) with 350-fold selectivity toward GSK-3compared to CDKs.

2 mg

$93

%410-%


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