1a. Amyloid beta (1-42) and Fragments
1b. AICD Fragments derived from Prepro-APP Pathway
Schematic diagram of APP sequential processing (not drawn in
scale). EC: extracellular; TM: transmembrane; IC: intracellular. AB
domain is highlighted in red. For simplicity, only one cleavage site is
shown for each enzyme.
Hui Zheng and Edward H Koo, Mol Neurodegener.
2006; 1 : 5.
APP Intracellular Domain (AICD) Contributes to AD Pathology
Independently of AB
1c. Other Soluble Fragments of Amyloid Precursor Proteins
Schematic of the different peptides administered to rats post-injury by Corrigan et. Al.
Human beta-Amyloid Precursor Sequence and Derived Peptides