Wiegand S., et al. European Journal of Endocrinology
(2004) 151 199–206
Glucose sensing is among the most conserved pathways in
human evolution, given its vital importance for brain
and immune system metabolism. These two systems are hypothesized
to interact to obtain glucose, no matter the cost, from
adipose, liver, and muscle tissues, even at the expense
of pancreas exhaustion. Evolutively, the price to pay
was very low. Those individuals with cytokine and metabolic
genetic polymorphisms that implicated the best external/internal
defense, preserving glucose for brain, immune system,
placenta, and mammary gland, the classical insulin-independent
tissues, survived and transmitted their genes.
Balance of proinflammatory and antiinflammatory agents
regulating the acute-phase response. An adequate balance
will lead to resolution of the process.
