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Angiotensin

Angiotensin, a peptide hormone, causes blood vessels to constrict, and drives blood pressure up. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the release of aldosterone, another hormone, from the adrenal cortex. Aldosterone promotes sodium retention in the distal nephron, in the kidney, which also drives blood pressure up.

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Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.

Santos RA, et al. Proc Natl Acad Sci U S A. 2003 Jun 26 [Epub ahead of print]

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Characterization of a new selective antagonist for angiotensin-(1-7), D-pro7-angiotensin-(1-7)

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Angiotensin IV in the central nervous system

 Von Bohlen Und Halbach O. Cell Tissue Res 2003 Jan;311(1):1-9

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Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system

Nagata S., et al. BBR C 350 (2006) 1026-1031

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Angiotensin II-induced cardiomyocyte hypertrophy in vitro is TAK1-dependent and Smad2/3-independent

Sarah J Watkins et al., Hyper. Research (2012) 35, 393–398; doi:10.1038/hr.2011.196; published online 10 November 2011

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Identification and characterization of a functional mitochondrial angiotensin system

Peter M. Abadir et al, PNAS August 18, 2011, doi: 10.1073/pnas.1101507108

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Angiotensin II sustains brain inflammation in mice via TGF-β

Tobias V. Lanz et al., J Clin Invest. 2010;120(8):2782–2794. doi:10.1172/JCI41709

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Cyclophilin A enhances vascular oxidative stress and the development of angiotensin IIĘCinduced aortic aneurysms

Kimio Satoh et al., Nature Medicine 15, 649 - 656 (2009)

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Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling.

Gusev K et al., Circ Res. 2009 Jul 2;105(1):42-50. Epub 2009 May 28.

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Mass-Spectrometric Identification of a Novel Angiotensin Peptide in Human Plasma

Jankowski V, et al. Arterioscler Thromb Vasc Biol. 2006 Nov 30; [Epub ahead of print]

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Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist

Circ Res. 2004 Jun 11;94(11):1451-7. Epub 2004 Apr 29

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Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats

Gironacci MM, et al. Regul Pept. 2004 Apr 15;118(1-2):45-9

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Effect of I.C.V. injection of AT4 receptor ligands, NLE1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats

Lee J, et al. Neuroscience. 2004;124(2):341-9

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AT(4) receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement

Albiston AL, et al. Trends Endocrinol Metab 2003 Mar;14(2):72-7

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Neuropeptide conversion to bioactive fragments - an important pathway in neuromodulation

Hallberg M, Nyberg F. Curr Protein Pept Sci 2003 Feb;4(1):31-44

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Cellular targets for angiotensin II fragments: pharmacological and molecular evidence

Vauquelin G, et al. J Renin Angiotensin Aldosterone Syst 2002 Dec;3(4):195-204

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Comparative effects of angiotensin IV and two hemorphins on angiotensin-converting enzyme activity

Fruitier-Arnaudin I, et al. Peptides 2002 Aug;23(8):1465-70

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Effects of angiotensins II and IV on blood pressure, renal function, and PAI-1 expression in the heart and kidney of the rat

Abrahamsen CT, et al. Pharmacology 2002 Sep;66(1):26-30

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Stimulation of collagen gel contraction by angiotensin II and III in cardiac fibroblasts

Lijnen P, et al. J Renin Angiotensin Aldosterone Syst 2002 Sep;3(3):160-6

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Angiotensin IV is a potent agonist for constitutive active human AT1 receptors. Distinct roles of the N-and C-terminal residues of angiotensin II during AT1 receptor activation

Le MT, et al. J Biol Chem 2002 Jun 28;277(26):23107-10

New Anti-Angiotensin I/II (1-7) Antibody for immunohistochemistry

H-002-24

angiotensin II

Pre-immuno Serum

G-002-24

angiotensin II

Pre-immuno Serum

H-002-24

H-002-12

Standard Curves

EK-002-01

Linear Range 0.1-1.09 ng/ml

Links to publications that use this peptide:

Bhatia K et al., Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.

Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1233. El-Remessey, Azza [corrected to El-Remessy, Azza B].

Boesen EI et al., ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells.

J Am Soc Nephrol. 2011 Dec;22(12):2187-92. Epub 2011 Oct 21.

Kittikulsuth W et al., Sex differences in renal medullary endothelin receptor function in angiotensin II hypertensive rats.

Hypertension. 2011 Aug;58(2):212-8. Epub 2011 Jun 6.

Alia Shatanawi et al., Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

Am J Physiol Cell Physiol. 2011 May; 300(5): C1181–C1192.

Park et al. Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice.

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1504-11.

Socha et al. Secreted Protein Acidic and Rich in Cysteine Deficiency Ameliorates Renal Inflammation and Fibrosis in Angiotensin Hypertension

Am J Pathol. 2007 Oct;171(4):1104-12.

Park et al. Compromised renal microvascular reactivity of angiotensin type 1 double null mice

Am J Physiol Renal Physiol. 2007 Jul;293(1):F60-7.

Ortiz et al. Aldosterone receptor antagonism exacerbates intrarenal angiotensin II augmentation in ANG II-dependent hypertension

Am J Physiol Renal Physiol. 2007 Jul;293(1):F139-47.

Zemse et al. Interleukin-10 counteracts impaired endothelium-dependent relaxation induced by ANG II in murine aortic rings

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3103-8. 

Kang et al. Novel Nitric Oxide Synthase–Dependent Mechanism of Vasorelaxation in Small Arteries From Hypertensive Rats

Hypertension. 2007 Apr;49(4):893-901.

Elmarakby et al. Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension

Vascul Pharmacol. 2007 Feb;46(2):144-51.

Latchford et al. Angiotensin II Activates a Nitric-Oxide-Driven Inhibitory Feedback in the Rat Paraventricular Nucleus.

J Neurophysiol. 2003 Mar;89(3):1238-44.

Miniati et al. Ex Vivo Antisense Oligonucleotides to Proliferating Cell Nuclear Antigen and Cdc2 Kinase Inhibit Graft Coronary Artery Disease.

Circulation. 2000 Nov 7;102(19 Suppl 3):III237-42.

Type-1 Angiotensin II

%angiotensin%


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