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Manserin

A novel peptide from secretogranin II in the neuroendocrine system

A novel peptide from secretogranin II in the neuroendocrine system

Secretogranin II (Sgll) is an acidic secretory protein, which was originally designated as chromogranin C. Sgll retains a number of pairs of basic residues within its amino acid sequence which are sites at which proteolytic processing could cleave smaller peptides from the precursor protein. Several peptides cleaved from Sgll are reported to date, including secretoneurin and EM-66. Secretoneurin, a 33 amino acid peptide, can be found as immunoreactive fibers throughout the central nervous system, however, higher concentrations are observed in hypothalamus, especially in the median eminence. The most important function of secretoneurin in the central nervous system is the regulation of neurotransmitter systems, including dopamine release in vitro as well as in vivo. EM-66, a 66 amino acid peptide has its immunoreactivity in the pituitary anterior lobe, and adrenal medulla in the rat, suggesting its distinct role in the endocrine system. However, judging from the putative cleavage sites of the basic residue pairs in the amino acid sequence of SgII, there remains a possibility that other peptides are produced by proteolytic processing of Sgll, but have not yet been investigated. Thus, we sought in this study to investigate the existence of a novel 40 amino acid peptide processed from Sgll (AA529-568), designated manserin, in the rat neuroendocrine system. In addition, by comparing cellular localizations between Sgll and manserin, we aimed to suggest a distinct function for manserin in the rat.

Aika Yajima et al. Neuroreport. 2004 Aug 6 (15-2):1755-59

Manserin / Prepro Secretogranin II (529-568) (Rat) (H-047-98) Antibody in Human Pancreas Tissue

 

Secretogranin II (Rat) Western Blot Kit (WBK-047-69)
using Rabbit Anti-EM-66 / Secretogranin II (219-284) (rat) antiserum (H-047-69)

Secretogranin II (Rat) Precursor Sequence & Scheme

Secretoneurin;other_biomarker_alzheimer

%Manserin%;%EM-66%


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