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Pyroglutamate Amyloid-β Peptides

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Alzheimer's aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on cu coordination.

Drew SC, et al. PLoS One. 2010 Dec 30;5(12):e15875.

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Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease.

Morawski M, et al. Acta Neuropathol. 2010 Aug;120(2):195-207. Epub 2010 Apr 10.

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pE-Aβ Aggregates in Human AD Edinger–Westphal Nucleus, Locus Coeruleus and Nucleus Basalis Meynert.

Morawski M et al., Acta Neuropathol. 2010 Aug;120(2):195 207

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Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

Britschgi M, et al. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12145-50. Epub 2009 Jul 6

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IgGs to Aβ are Present in Human CSF, Protect Neurons from Aβ Toxicity in vitro, and are Amplified Together with ABri and ADan Cross-Reactive Antibodies in an Aβ Immunization Paradigm.

Biritschgi M, et al. PNAS. 2009 Jul 21;106(29):12145-50

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Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease.

Gunn AP, et al. Int J Biochem Cell Biol. 2010 Dec;42(12):1915-8. Epub 2010 Sep 15.

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Identification of low molecular weight pyroglutamate abeta oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.

Wirths O, et al. J Biol Chem. 2010 Dec 31;285(53):41517-24. Epub 2010 Oct 22.

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Anti-11[E]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological Aβ species: Relevance for immunotherapy.

Perez-Garmendia R, et al. J Neuroimmunol. 2010 Dec 15;229(1-2):248-55. Epub 2010 Sep 22.

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Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease.

Portelius E, et al. Acta Neuropathol. 2010 Aug;120(2):185-93

amyloid_beta_peptides;Amyloid_beta_precursor_like

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