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β-Amyloid

a. Amyloid beta (1-42) and fragments
b. AICD (APP intracellular domain)
c. Soluble fragments of Amyloid Precursor Proteins

 

1a. Amyloid beta (1-42) and Fragments

 

Amyloid-β Related Products

%Amyloid beta%

 

1b. AICD Fragments derived from Prepro-APP Pathway

Schematic diagram of APP sequential processing (not drawn in scale). EC: extracellular; TM: transmembrane; IC: intracellular. AB domain is highlighted in red. For simplicity, only one cleavage site is shown for each enzyme.

Hui Zheng and Edward H Koo, Mol Neurodegener. 2006; 1 : 5.

 

APP Intracellular Domain (AICD) Contributes to AD Pathology Independently of AB

AICD (Short form of APP Intracellular Domain) (Human) / Beta-Amyloid Precursor (727-770), (018-69)

Long Form of APP Intracellular Domain (AICD) (Human) = Human Beta-Amyloid Precursor (712-770), (018-70)

 

APP Intracellular Domain (AICD) Related Products

%AICD%;%C-31%

 

1c. Other Soluble Fragments of Amyloid Precursor Proteins

Schematic of the different peptides administered to rats post-injury by Corrigan et. Al.

 

β-Amyloid Precursor Related Products

%018-65%;%018-66%;%018-67%

1a. Amyloid beta (1-42) and Fragments

Click to Collapse

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease.   

Cross-Sectional Analyses of Clinical, Cognitive, Structural, Metabolic, and Biochemical Changes in Autosomal Dominant Alzheimer’s Disease Mutation Carriers versus Noncarriers, According to Estimated Years from Expected Symptom Onset. Dashed lines represent 95% confidence intervals of the fitted curves. SUVR denotes standardized uptake value ratio.

Randall J. Bateman et al., NEJM , 367 (9): 795- 804, 2012

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Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang et al. Proc Natl Acad Sci U S A. 2010 Mar 22.

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Pyroglutamate-AB: Role in the natural history of Alzheimer's disease.

Gunn AP, et al. Int J Biochem Cell Biol. 2010 Dec;42(12):1915-8. Epub 2010 Sep 15.

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Identification of low molecular weight pyroglutamate abeta oligomers in Alzheimer disease

Wirths O, et al. J Biol Chem. 2010 Dec 31;285(53):41517-24. Epub 2010 Oct 22.

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Anti-11[E]-pyroglutamate-modified amyloid B antibodies cross-react with other pathological AB species: Relevance for immunotherapy.

Perez-Garmendia R, et al. J Neuroimmunol. 2010 Dec 15;229(1-2):248-55. Epub 2010 Sep 22.

Amyloid-β Related Products

%Amyloid beta%

Amyloid β-Protein (1-40) (Human) ELISA Kit (EK-018-01)

Human beta-Amyloid Precursor Sequence and Derived Peptides

Tips: See More Research Abstracts, Antibody Stainings, Immunoassay Kits Curves and Sequences by clicking the tabs on the top.

AB_Dimer;amyloid_beta_precursor_like;Pyroglutamate

%amyloid%


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