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Orphan Receptor


 
Receptor Ligand Reference
FM3 Neuromedin U 22, 23
HLWAR77 Neuropeptide FF and AF 21
GPR14 Urotensin II 2, 3,14,15
SLC-1/MCH receptor MCH 4, 16
HGR-3/GPR-10/UHR-1 Prolactin-Releasing Peptide 1,5,6
HFGAN-72 Orexins/Hypocretins 1, 7, 8
APJ Apelin 1, 9,17
ORL-1/IC-132 Orphanin FQ/Nociceptin 1, 10, 11
GRL-104 PSFHSWS-Amide 1, 12
GRL-106 LyCEP 1, 13
 

Newly Identified Endogenous  Ligand for Receptor


 
Receptor Ligand Reference
FM3 Neuromedin U 22, 23
HLWAR77 Neuropeptide FF and AF 21
GHS-Rs Ghrelin/Des-Q14-Ghrelin (Rat) 18
GALR1, GALR2 Galanin like Peptide 19
Motilin Receptor Motilin (Human) 24
PTH2 Receptor TIP39/TIP(7-39) 20
 


References:
  1. Hinuma, S., et al. The quest for novel bioactive peptides utilizing orphan seven-membrane-domain receptors.
    Journal of Molecular Medicine 77, 495-504 (1999)

  2. Ames, R.S., et al. Human urotensin II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
    Nature 401, 282-286 (1999)

  3. Nothacker, H.-P. et al., Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nature Cell Biology 1, 383-385 (1999)

  4. Chambers, J. et al., Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
      Nature 400, 261-265 (1999)

  5. Hinuma, S. et al., Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene. Biochemica Biophysica acta 1219, 251-259 (1994)

  6. Fujii, R., et al. Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.
    Regulatory Peptides (1999, in press)

  7. Lecea, L., et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
    PNAS 95, 322-327 (1998)

  8. Sakurai, T.S., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-couples receptors that regulate feeding     behavior. cell 92,573-585(1998)

  9. Tatemoto K., et al. isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251, 471-476 (1998)

  10. Meunier, J-C., et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature    377,532-535(1995)

  11. Reinscheid, R. K., et al. Orphanin FQ: A neuropeptide that activates an opioid-like G protein -coupled receptor. Science 270,792-794(1995)

  12. Cox, K. J.A. et al. Cloning, characterization, and expression of a G-protein-coupled receptor from Lymnaea stagnails and identification of a leucokinin-like peptide, FSFHSWSamide, as its endogenous ligand. J Neurosci 17,1197-1205(1997)

  13. Tensen, C. P., et al. The Lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the Rfamide neuropeptide family. J Neurosci 18,9812-9821(1998)

  14. Liu, Q., et al. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.Biochem Biophys Res Commun 266,174-178(1999)

  15. Mori, M., et al. Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GP R14).Biochem Biophys Res Commun. 265, 123-129(1999).
  16. Lembo, P. M., et al.The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.
    Nat Cell Biolog. 1, 267-271(1999)

  17. Habata, Y., et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum.
    Biochim Biophys Acta. 1452, 25-35(1999)

  18. Kojima, M., et al.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach.  Nature 402,656-660(1990)

  19. Ohtaki, T, et al. Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J Biol Chem    274,37041-37045(1990)

  20. Usdin, T.B. et al. TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nat Neurosci 2,941-943(1990)

  21. Elshourbagy N.A., et al. Receptor for the Pain Modulatory Neuropeptides NPFF and NPAF is an Orphan G-Protein-Coupled Receptor. JBC (June 12, 2000)

  22. Szekeres, P.G., et al. Neuromedin U is a potent agonist at the orphan G protein coupled receptor FM3. JBC (May 12, 2000)

  23. Fujii R., et al. Identification of Neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. JBC (April 26, 2000)

  24. Feighner SD, et al. Receptor for motilin identified in the human gastrointestinal system. Science 1999 Jun 25;284(5423):2184-8. 



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