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WKYMVM
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An agonist for the orphan receptor chemoattractant receptor FPRL1 and FPRL2.
Different chemoattractants induce leukocyte infiltration and activation through binding to G protein-coupled receptor. FPRL1, and FPRL2 belong to the N-formyl peptide chemoattractant G protein-coupled receptor family (FPR). Two synthetic hexapeptides Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) and Trp-Lys-Tyr-Met-Val-D-Met-NH2 (WKYMVm) specifically bind to FPRL1 and FPRL2. Its L or D conformers also induce phosphorylation and internalization of FPRL1. The data indicated that neutrophils are activated by WKYMVM through FPRL1 and FPRL2 is a chemotactic receptor transducing signals in myeloid cells. Christophe, T. et al. J. Biol. Chem. online April 02, 2001
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Want to visualize FPRL1 and FPRL2 dynamic trafficking in living cells? Try fluorescent WKYMVM / WKYMVm !!! |
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Monitoring Formylated Peptide Receptor with Fluorescent Peptide |
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